TCU will play Iowa State at 2:30 p.m. in Amon G. Carter Stadium on Oct. 6.
The game will be televised nationally on FOX Sports Net.
TCU and Iowa State will meet for the first time since a 27-24 Horned Frog victory in the 2005 Houston Bowl.
The 14th-ranked Horned Frogs (3-0, 1-0) have the nation's longest winning streak at 11 games. The team defeated Kansas, 20-6, in its Big 12 opener on Sept. 8 in Lawrence, KS.
TCU will play at SMU Sept. 29 at 6 p.m. The game can be seen on FOX Sports Net.